BRENDA - Enzyme Database
show all sequences of 2.7.11.9

Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis

Raya, A.; Revert-Ros, F.; Martinez-Martinez, P.; Navarro, S.; Rosello, E.; et al.; J. Biol. Chem. 275, 40392-40399 (2000)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
-
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + goodpasture antigen
Homo sapiens
enzyme is involved in autoimmune pathogenesis. Enzyme expression is up-regulated in the striated muscle of a Goodpasture patient and in other autoimmune conditions including cutaneous lupus erythematosus, pemphigoid, and lichen planus
ADP + phosphorylated goodpasture antigen
-
Homo sapiens
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
Q9GKI7
-
-
Homo sapiens
Q9Y5P4
-
-
Mus musculus
Q9EQG9
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cell culture
HeLa cells
Homo sapiens
-
additional information
enzyme is preferentially expressed in small vessels and histological structures targeted by natural autoimmune responses including alveolar and glomerular basement membranes
Bos taurus
-
additional information
preferential expression in the histological structures that are targets of common autoimmune responses
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + goodpasture antigen
phosphorylation in the N-terminal region of the goodpasture antigen
491668
Homo sapiens
ADP + phosphorylated goodpasture antigen
-
491668
Homo sapiens
?
ATP + goodpasture antigen
enzyme is involved in autoimmune pathogenesis. Enzyme expression is up-regulated in the striated muscle of a Goodpasture patient and in other autoimmune conditions including cutaneous lupus erythematosus, pemphigoid, and lichen planus
491668
Homo sapiens
ADP + phosphorylated goodpasture antigen
-
491668
Homo sapiens
?
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + goodpasture antigen
Homo sapiens
enzyme is involved in autoimmune pathogenesis. Enzyme expression is up-regulated in the striated muscle of a Goodpasture patient and in other autoimmune conditions including cutaneous lupus erythematosus, pemphigoid, and lichen planus
ADP + phosphorylated goodpasture antigen
-
Homo sapiens
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cell culture
HeLa cells
Homo sapiens
-
additional information
enzyme is preferentially expressed in small vessels and histological structures targeted by natural autoimmune responses including alveolar and glomerular basement membranes
Bos taurus
-
additional information
preferential expression in the histological structures that are targets of common autoimmune responses
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + goodpasture antigen
phosphorylation in the N-terminal region of the goodpasture antigen
491668
Homo sapiens
ADP + phosphorylated goodpasture antigen
-
491668
Homo sapiens
?
ATP + goodpasture antigen
enzyme is involved in autoimmune pathogenesis. Enzyme expression is up-regulated in the striated muscle of a Goodpasture patient and in other autoimmune conditions including cutaneous lupus erythematosus, pemphigoid, and lichen planus
491668
Homo sapiens
ADP + phosphorylated goodpasture antigen
-
491668
Homo sapiens
?
Other publictions for EC 2.7.11.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737750
Hanada
Co-evolution of sphingomyelin ...
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Biochim. Biophys. Acta
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722751
Mencarelli
Goodpasture antigen-binding pr ...
Homo sapiens
J. Biol. Chem.
287
14897-14911
2012
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6
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722724
Revert-Ros
Goodpasture antigen-binding pr ...
Mus musculus
J. Biol. Chem.
286
35030-35043
2011
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722667
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Homo sapiens
J. Biol. Chem.
285
12551-12558
2010
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704804
Mencarelli
The expression of the Goodpast ...
Rattus norvegicus
J. Chem. Neuroanat.
38
97-105
2009
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693093
Granero-Molto
Goodpasture antigen-binding pr ...
Danio rerio
J. Biol. Chem.
283
20495-20504
2008
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1
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693162
Revert
Goodpasture antigen-binding pr ...
Homo sapiens
J. Biol. Chem.
283
30246-30255
2008
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1
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5
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661708
Granero
A human-specific TNF-responsiv ...
Homo sapiens
FEBS J.
272
5291-5305
2005
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491667
Kawai
Functional annotation of a ful ...
Mus musculus
Nature
409
685-690
2001
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491668
Raya
Goodpasture antigen-binding pr ...
Bos taurus, Homo sapiens, Mus musculus
J. Biol. Chem.
275
40392-40399
2000
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491669
Raya
Characterization of a novel ty ...
Homo sapiens
J. Biol. Chem.
274
12642-12649
1999
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