Literature summary for 2.7.11.8 extracted from

Zhang, F.; Wang, K.; Zhang, S.; Li, J.; Fan, R.; Chen, X.; Pei, J.
Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy (2020), Redox Biol., 38, 101778 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9JIX9	-	-

Synonyms

Synonyms	Comment	Organism
FASTK	-	Mus musculus

General Information

General Information	Comment	Organism
drug target	restoration of FASTK expression through genetic approaches might be a promising therapeutic strategy for alcoholic cardiomyopathy (ACM)	Mus musculus
malfunction	compared to wild type control, alcohol-related myocardial morphological (hypertrophy, fibrosis and cardiomyocyte apoptosis) and functional (reduced ejection fraction and compromised cardiomyocyte contraction) anomalies are worsened in FASTK deficient mice	Mus musculus
physiological function	the enzyme is a key post-transcriptional regulator of mitochondrial gene expression. Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy	Mus musculus

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Release 2023.1 (January 2023)