Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.8 extracted from

  • Li, W.; Simarro, M.; Kedersha, N.; Anderson, P.
    FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression (2004), Mol. Cell. Biol., 24, 10178-10732.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.8

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of HA-tagged enzyme in HeLa cells and in COS-7 cells, recombinant FAST promotes the expression of co-transfected reporter proteins, e.g. beta-galactosidase, via its TIA-1 binding domain, and increases the expression of endogenous cIAP-1 and XIAP, but not GAPDH, in HeLa cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane interaction with BCL-XL Homo sapiens 5741
-
mitochondrion enzyme has a mitochondrial targeting domain Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + TIA-1 Homo sapiens FAST serves as a sensor for mitochondrial stress modulating a TIA-1 regulated posttranscriptional stress response program, FAST might prevent TIA-1 mediated silencing of mRNA encoding inhibitors of of apoptosis ADP + phosphorylated TIA-1
-
 ?
ATP + [Fas-activated serine/threonine protein] Homo sapiens
-
 ADP + [Fas-activated serine/threonine phosphoprotein]
-
 ?
additional information Homo sapiens FAST serves as a sensor for mitochondrial stress modulating a TIA-1 regulated posttranscriptional stress response program, FAST is a survival protein, modulating the NF-kappaB-dependent survival pathway, and has antiapoptotic effects inhibiting Fas-and UV-induced apoptosis, involving activation of caspase-3, its antiapoptotic effects are inhibited by TIA-1, FAST might prevent TIA-1 mediated silencing of mRNA encoding inhibitors of of apoptosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14296
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + TIA-1
-
 Homo sapiens ADP + phosphorylated TIA-1
-
 ?
ATP + TIA-1 FAST serves as a sensor for mitochondrial stress modulating a TIA-1 regulated posttranscriptional stress response program, FAST might prevent TIA-1 mediated silencing of mRNA encoding inhibitors of of apoptosis Homo sapiens ADP + phosphorylated TIA-1
-
 ?
ATP + [Fas-activated serine/threonine protein]
-
 Homo sapiens ADP + [Fas-activated serine/threonine phosphoprotein]
-
 ?
additional information FAST serves as a sensor for mitochondrial stress modulating a TIA-1 regulated posttranscriptional stress response program, FAST is a survival protein, modulating the NF-kappaB-dependent survival pathway, and has antiapoptotic effects inhibiting Fas-and UV-induced apoptosis, involving activation of caspase-3, its antiapoptotic effects are inhibited by TIA-1, FAST might prevent TIA-1 mediated silencing of mRNA encoding inhibitors of of apoptosis Homo sapiens ?
-
 ?
additional information the enzyme interacts with BCL-XL at the outer mitochondrial membrane Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Fas-activated serine/threonine phosphoprotein
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens