Cloned (Comment) | Organism |
---|---|
overexpression of HA-tagged enzyme in HeLa cells and in COS-7 cells, expression of GFP-tagged enzyme in COS-7 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | enzyme has a mitochondrial targeting domain | Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [Fas-activated serine/threonine protein] | Homo sapiens | - |
ADP + [Fas-activated serine/threonine phosphoprotein] | - |
? | |
additional information | Homo sapiens | the interaction of the enzyme with protein BCL-XL is involved in regulation of mitochondrial metabolism during Fas-induced apoptosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q14296 | - |
- |
Purification (Comment) | Organism |
---|---|
partially, subcellular fractionation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [Fas-activated serine/threonine protein] | - |
Homo sapiens | ADP + [Fas-activated serine/threonine phosphoprotein] | - |
? | |
additional information | the interaction of the enzyme with protein BCL-XL is involved in regulation of mitochondrial metabolism during Fas-induced apoptosis | Homo sapiens | ? | - |
? | |
additional information | the enzyme interacts with BCL-XL requiring the BCL-2-homology-3 (BH3)-related domain and the MTD domain of BCL-XL | Homo sapiens | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |