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Literature summary for 2.7.11.8 extracted from

  • Li, W.; Kedersha, N.; Chen, S.; Gilks, N.; Lee, G.; Anderson, P.
    FAST is a BCL-XL-associated mitochondrial protein (2004), Biochem. Biophys. Res. Commun., 318, 95-102.
    View publication on PubMed
Search for more literature for 2.7.11.8

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of HA-tagged enzyme in HeLa cells and in COS-7 cells, expression of GFP-tagged enzyme in COS-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion enzyme has a mitochondrial targeting domain Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [Fas-activated serine/threonine protein] Homo sapiens
-
 ADP + [Fas-activated serine/threonine phosphoprotein]
-
 ?
additional information Homo sapiens the interaction of the enzyme with protein BCL-XL is involved in regulation of mitochondrial metabolism during Fas-induced apoptosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14296
-
-

Purification (Commentary)

Purification (Comment) Organism
partially, subcellular fractionation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [Fas-activated serine/threonine protein]
-
 Homo sapiens ADP + [Fas-activated serine/threonine phosphoprotein]
-
 ?
additional information the interaction of the enzyme with protein BCL-XL is involved in regulation of mitochondrial metabolism during Fas-induced apoptosis Homo sapiens ?
-
 ?
additional information the enzyme interacts with BCL-XL requiring the BCL-2-homology-3 (BH3)-related domain and the MTD domain of BCL-XL Homo sapiens ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens