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Literature summary for 2.7.11.8 extracted from

  • Tian, Q.; Taupin, J.; Elledge, S.; Robertson, M.; Anderson, P.
    Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis (1995), J. Exp. Med., 182, 865-874.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information rapidly activated during Fas-mediated apoptosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + TIA-1 Homo sapiens rapidly activated during Fas-mediated apoptosis. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation, suggesting a role in signaling downstream events in the apoptotic program ADP + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14296
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein enzyme is phosphorylated on serine and threonine residues. In response to Fas ligation, it is rapidly dephosphorylated and concomitantly activated to phosphorylate TIA-1 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + TIA-1
-
 Homo sapiens ADP + ?
-
 ?
ATP + TIA-1 rapidly activated during Fas-mediated apoptosis. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation, suggesting a role in signaling downstream events in the apoptotic program Homo sapiens ADP + ?
-
 ?

Synonyms

Synonyms Comment Organism
Fas-activated serine/threonine kinase
-
 Homo sapiens