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Literature summary for 2.7.11.5 extracted from

  • Singh, S.K.; Miller, S.P.; Dean, A.; Banaszak, L.J.; LaPorte, D.C.
    Bacillus subtilis isocitrate dehydrogenase. A substrate analogue for Escherichia coli isocitrate dehydrogenase kinase/phosphatase (2002), J. Biol. Chem., 277, 7567-7573.
    View publication on PubMed
Search for more literature for 2.7.11.5

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00078
-
 [isocitrate dehydrogenase (NADP+)] pH 7.5, 37°C, kinase activity at saturating ATP Escherichia coli
0.0049
-
 Bacillus subtilis [isocitrate dehydrogenase (NADP+)] pH 7.5, 37°C Escherichia coli
0.0059
-
 [isocitrate dehydrogenase (NADP+)] pH 7.5, 37°C Escherichia coli
0.0582
-
 Bacillus subtilis [isocitrate dehydrogenase (NADP+)] pH 7.5, 37°C, kinase activity at saturating ATP Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [isocitrate dehydrogenase (NADP+)] Escherichia coli phosphorylation of isocitrate dehydrogenase during growth on acetate is to render this enzyme rate-limiting in the citric acid cycle, this should cause an increase in the level of isocitrate and divert the flux of carbon through the glyoxylate bypass ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Bacillus subtilis [isocitrate dehydrogenase (NADP+)] BsIDH is a much poorer substrate for the enzyme than EcIDH Escherichia coli ADP + Bacillus subtilis [isocitrate dehydrogenase (NADP+)] phosphate
-
 ?
ATP + [isocitrate dehydrogenase (NADP+)]
-
 Escherichia coli ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r
ATP + [isocitrate dehydrogenase (NADP+)] phosphorylation of isocitrate dehydrogenase during growth on acetate is to render this enzyme rate-limiting in the citric acid cycle, this should cause an increase in the level of isocitrate and divert the flux of carbon through the glyoxylate bypass Escherichia coli ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r