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Literature summary for 2.7.11.5 extracted from

  • Miller, S.P.; Chen, R.; Karschnia, E.J.; Romfo, C.; Dean, A.; LaPorte, D.C.
    Locations of the regulatory sites for isocitrate dehydrogenase kinase/phosphatase (2000), J. Biol. Chem., 275, 833-839.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-phosphoglycerate
-
Escherichia coli
AMP
-
Escherichia coli
DL-isocitrate inhibits only kinase activity Escherichia coli
NADPH inhibits both IDH kinase and IDH phosphatase Escherichia coli
pyruvate
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0009
-
[isocitrate dehydrogenase (NADP+)]N15L pH 7.5, 37°C Escherichia coli
0.0017
-
[isocitrate dehydrogenase (NADP+)] pH 7.5, 37°C Escherichia coli
0.02
-
[isocitrate dehydrogenase (NADP+)]IS pH 7.5, 37°C Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [isocitrate dehydrogenase (NADP+)] Escherichia coli
-
ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [isocitrate dehydrogenase (NADP+)]
-
Escherichia coli ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
r
ATP + [isocitrate dehydrogenase (NADP+)]IS
-
Escherichia coli ADP + [isocitrate dehydrogenase (NADP+)]IS phosphate
-
?
ATP + [isocitrate dehydrogenase (NADP+)]N115L
-
Escherichia coli ADP + [isocitrate dehydrogenase (NADP+)]N115L phosphate
-
?
ATP + [isocitrate dehydrogenase (NADP+)]N15L
-
Escherichia coli [isocitrate dehydrogenase (NADP+)]N15L phosphate
-
?

Synonyms

Synonyms Comment Organism
isocitrate dehydrogenase kinase/phosphatase
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.008
-
AMP pH 7.5, 37°C Escherichia coli
0.011
-
isocitrate pH 7.5, 37°C, mutant AceK4, kinase activity Escherichia coli
0.015
-
isocitrate pH 7.5, 37°C, mutant AceK3, kinase activity Escherichia coli
0.016
-
isocitrate pH 7.5, 37°C, wild-type, kinase activity Escherichia coli
0.02
-
AMP pH 7.5, 37°C, mutant AceK4, kinase activity Escherichia coli
0.058
-
NADPH pH 7.5, 37°C, mutant AceK4, kinase activity Escherichia coli
0.073
-
NADPH pH 7.5, 37°C, mutant AceK3, kinase activity Escherichia coli
0.082
-
NADPH pH 7.5, 37°C, wild-type, kinase activity Escherichia coli
0.17
-
AMP pH 7.5, 37°C, mutant AceK3, kinase activity Escherichia coli
0.2
-
pyruvate pH 7.5, 37°C, wild-type, kinase activity Escherichia coli
1
-
pyruvate pH 7.5, 37°C, mutant AceK4, kinase activity Escherichia coli
1
-
3-phosphoglycerate pH 7.5, 37°C, wild-type, kinase activity Escherichia coli
4
-
3-phosphoglycerate pH 7.5, 37°C, mutant AceK4, kinase activity Escherichia coli
4
-
pyruvate pH 7.5, 37°C, mutant AceK3, kinase activity Escherichia coli
20
-
3-phosphoglycerate pH 7.5, 37°C, mutant AceK3, kinase activity Escherichia coli