Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-phosphoglycerate | - |
Escherichia coli | |
AMP | - |
Escherichia coli | |
DL-isocitrate | inhibits only kinase activity | Escherichia coli | |
NADPH | inhibits both IDH kinase and IDH phosphatase | Escherichia coli | |
pyruvate | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0009 | - |
[isocitrate dehydrogenase (NADP+)]N15L | pH 7.5, 37°C | Escherichia coli | |
0.0017 | - |
[isocitrate dehydrogenase (NADP+)] | pH 7.5, 37°C | Escherichia coli | |
0.02 | - |
[isocitrate dehydrogenase (NADP+)]IS | pH 7.5, 37°C | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [isocitrate dehydrogenase (NADP+)] | Escherichia coli | - |
ADP + [isocitrate dehydrogenase (NADP+)] phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [isocitrate dehydrogenase (NADP+)] | - |
Escherichia coli | ADP + [isocitrate dehydrogenase (NADP+)] phosphate | - |
r | |
ATP + [isocitrate dehydrogenase (NADP+)]IS | - |
Escherichia coli | ADP + [isocitrate dehydrogenase (NADP+)]IS phosphate | - |
? | |
ATP + [isocitrate dehydrogenase (NADP+)]N115L | - |
Escherichia coli | ADP + [isocitrate dehydrogenase (NADP+)]N115L phosphate | - |
? | |
ATP + [isocitrate dehydrogenase (NADP+)]N15L | - |
Escherichia coli | [isocitrate dehydrogenase (NADP+)]N15L phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
isocitrate dehydrogenase kinase/phosphatase | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
AMP | pH 7.5, 37°C | Escherichia coli | |
0.011 | - |
isocitrate | pH 7.5, 37°C, mutant AceK4, kinase activity | Escherichia coli | |
0.015 | - |
isocitrate | pH 7.5, 37°C, mutant AceK3, kinase activity | Escherichia coli | |
0.016 | - |
isocitrate | pH 7.5, 37°C, wild-type, kinase activity | Escherichia coli | |
0.02 | - |
AMP | pH 7.5, 37°C, mutant AceK4, kinase activity | Escherichia coli | |
0.058 | - |
NADPH | pH 7.5, 37°C, mutant AceK4, kinase activity | Escherichia coli | |
0.073 | - |
NADPH | pH 7.5, 37°C, mutant AceK3, kinase activity | Escherichia coli | |
0.082 | - |
NADPH | pH 7.5, 37°C, wild-type, kinase activity | Escherichia coli | |
0.17 | - |
AMP | pH 7.5, 37°C, mutant AceK3, kinase activity | Escherichia coli | |
0.2 | - |
pyruvate | pH 7.5, 37°C, wild-type, kinase activity | Escherichia coli | |
1 | - |
pyruvate | pH 7.5, 37°C, mutant AceK4, kinase activity | Escherichia coli | |
1 | - |
3-phosphoglycerate | pH 7.5, 37°C, wild-type, kinase activity | Escherichia coli | |
4 | - |
3-phosphoglycerate | pH 7.5, 37°C, mutant AceK4, kinase activity | Escherichia coli | |
4 | - |
pyruvate | pH 7.5, 37°C, mutant AceK3, kinase activity | Escherichia coli | |
20 | - |
3-phosphoglycerate | pH 7.5, 37°C, mutant AceK3, kinase activity | Escherichia coli |