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Literature summary for 2.7.11.5 extracted from

  • Miller, S.P.; Karschnia, E.J.; Ikeda, T.P.; LaPorte, D.C.
    Isocitrate dehydrogenase kinase/phosphatase. Kinetic characteristics of the wild-type and two mutant proteins (1996), J. Biol. Chem., 271, 19124-19128.
    View publication on PubMed
Search for more literature for 2.7.11.5

Cloned(Commentary)

Cloned (Comment) Organism
aceK gene Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
[isocitrate dehydrogenase (NADP+)] phosphate wild-type Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00023
-
 [isocitrate dehydrogenase (NADP+)] pH 7.5, 37°C, wild-type and mutant AceK4, kinase activity Escherichia coli
0.00025
-
 [isocitrate dehydrogenase (NADP+)] pH 7.5, 37°C, mutant AceK3, kinase activity Escherichia coli
0.016
-
 ATP pH 7.5, 37°C, wild-type, kinase activity Escherichia coli
0.1
-
 ATP pH 7.5, 37°C, mutant AceK3, kinase activity Escherichia coli
0.32
-
 ATP pH 7.5, 37°C, mutant AceK4, kinase activity Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [isocitrate dehydrogenase (NADP+)] Escherichia coli reversible phosphorylation of isocitrate dehydrogenase plays a major role in the control of the Krebs cycle and glyoxylate pathways ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r
ATP + [isocitrate dehydrogenase (NADP+)] Escherichia coli ST2010R reversible phosphorylation of isocitrate dehydrogenase plays a major role in the control of the Krebs cycle and glyoxylate pathways ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 ST2010R
-
Escherichia coli ST2010R
-
 ST2010R
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [isocitrate dehydrogenase (NADP+)]
-
 Escherichia coli ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r
ATP + [isocitrate dehydrogenase (NADP+)] reversible phosphorylation of isocitrate dehydrogenase plays a major role in the control of the Krebs cycle and glyoxylate pathways Escherichia coli ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r
ATP + [isocitrate dehydrogenase (NADP+)]
-
 Escherichia coli ST2010R ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r
ATP + [isocitrate dehydrogenase (NADP+)] reversible phosphorylation of isocitrate dehydrogenase plays a major role in the control of the Krebs cycle and glyoxylate pathways Escherichia coli ST2010R ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r