BRENDA - Enzyme Database show
show all sequences of 2.7.11.5

The reversible phosphorylation of isocitrate dehydrogenase of Salmonella typhimurium

Wang, J.Y.J.; Koshland, D.E.; Arch. Biochem. Biophys. 218, 59-67 (1982)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
2-deoxy-D-glucose
-
Salmonella enterica subsp. enterica serovar Typhimurium
acetate
-
Salmonella enterica subsp. enterica serovar Typhimurium
alpha-methylglucoside
-
Salmonella enterica subsp. enterica serovar Typhimurium
ethanol
-
Salmonella enterica subsp. enterica serovar Typhimurium
Inhibitors
Inhibitors
Commentary
Organism
Structure
glyoxylate
in combination with oxaloacetate
Salmonella enterica subsp. enterica serovar Typhimurium
oxaloacetate
-
Salmonella enterica subsp. enterica serovar Typhimurium
pyruvate
-
Salmonella enterica subsp. enterica serovar Typhimurium
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + [isocitrate dehydrogenase (NADP+)]
Salmonella enterica subsp. enterica serovar Typhimurium
reversible phosphorylation of isocitrate dehydrogenase plays a major role in the control of the Krebs cycle and glyoxylate pathways
ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + [isocitrate dehydrogenase (NADP+)]
-
640600
Salmonella enterica subsp. enterica serovar Typhimurium
ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
640600
Salmonella enterica subsp. enterica serovar Typhimurium
?
ATP + [isocitrate dehydrogenase (NADP+)]
reversible phosphorylation of isocitrate dehydrogenase plays a major role in the control of the Krebs cycle and glyoxylate pathways
640600
Salmonella enterica subsp. enterica serovar Typhimurium
ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
640600
Salmonella enterica subsp. enterica serovar Typhimurium
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
2-deoxy-D-glucose
-
Salmonella enterica subsp. enterica serovar Typhimurium
acetate
-
Salmonella enterica subsp. enterica serovar Typhimurium
alpha-methylglucoside
-
Salmonella enterica subsp. enterica serovar Typhimurium
ethanol
-
Salmonella enterica subsp. enterica serovar Typhimurium
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
glyoxylate
in combination with oxaloacetate
Salmonella enterica subsp. enterica serovar Typhimurium
oxaloacetate
-
Salmonella enterica subsp. enterica serovar Typhimurium
pyruvate
-
Salmonella enterica subsp. enterica serovar Typhimurium
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + [isocitrate dehydrogenase (NADP+)]
Salmonella enterica subsp. enterica serovar Typhimurium
reversible phosphorylation of isocitrate dehydrogenase plays a major role in the control of the Krebs cycle and glyoxylate pathways
ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + [isocitrate dehydrogenase (NADP+)]
-
640600
Salmonella enterica subsp. enterica serovar Typhimurium
ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
640600
Salmonella enterica subsp. enterica serovar Typhimurium
?
ATP + [isocitrate dehydrogenase (NADP+)]
reversible phosphorylation of isocitrate dehydrogenase plays a major role in the control of the Krebs cycle and glyoxylate pathways
640600
Salmonella enterica subsp. enterica serovar Typhimurium
ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
640600
Salmonella enterica subsp. enterica serovar Typhimurium
?
Other publictions for EC 2.7.11.5
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738248
Yin
Loopbeta3alphaC plays an impor ...
Escherichia coli
FEBS Lett.
590
3144-3154
2016
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723346
Zheng
Structural and mechanistic ins ...
Escherichia coli
Philos. Trans. R. Soc. Lond. B Biol. Sci.
367
2656-2668
2012
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721649
Yates
Structural basis of the substr ...
Burkholderia pseudomallei, Escherichia coli
Biochemistry
50
8103-8106
2011
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2
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723265
Zheng
Structure of the bifunctional ...
Escherichia coli 0157:H7, Escherichia coli
Nature
465
961-965
2010
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8
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1
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1
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8
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6
1
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3
3
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666105
Cozzone
Control of isocitrate dehydrog ...
Escherichia coli
J. Mol. Microbiol. Biotechnol.
9
132-146
2005
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640612
Singh
Bacillus subtilis isocitrate d ...
Escherichia coli
J. Biol. Chem.
277
7567-7573
2002
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640610
Oudot
The 'catalytic' triad of isoci ...
Escherichia coli, Escherichia coli JM109
Biochemistry
40
3047-3055
2001
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3
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4
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1
1
1
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3
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1
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640611
Singh
Crystal structure of Bacillus ...
Escherichia coli
J. Biol. Chem.
276
26154-26163
2001
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640609
Miller
Locations of the regulatory si ...
Escherichia coli
J. Biol. Chem.
275
833-839
2000
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3
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640608
Oudot
The isocitrate dehydrogenase k ...
Escherichia coli, Escherichia coli JM109
Eur. J. Biochem.
262
224-229
1999
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32
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640607
El-Mansi
Control of metabolic interconv ...
Escherichia coli
FEMS Microbiol. Lett.
166
333-339
1998
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640605
Miller
Isocitrate dehydrogenase kinas ...
Escherichia coli, Escherichia coli ST2010R
J. Biol. Chem.
271
19124-19128
1996
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640606
Rittinger
Escherichia coli isocitrate de ...
Escherichia coli
Eur. J. Biochem.
237
247-254
1996
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640604
Ikeda
Isocitrate dehydrogenase kinas ...
Escherichia coli, Escherichia coli W3550
J. Bacteriol.
174
1414-1416
1992
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640603
Varela
Photoaffinity labelling shows ...
Escherichia coli, Escherichia coli KAT-1/pEM9
FEBS Lett.
231
361-365
1988
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640601
Nimmo
Partial purification and prope ...
Escherichia coli
Eur. J. Biochem.
141
401-408
1984
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640602
Nimmo
The regulatory properties of i ...
Escherichia coli
Eur. J. Biochem.
141
409-414
1984
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640600
Wang
The reversible phosphorylation ...
Salmonella enterica subsp. enterica serovar Typhimurium
Arch. Biochem. Biophys.
218
59-67
1982
4
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