Literature summary for 2.7.11.4 extracted from

Kadota, Y.; Toyoda, T.; Hayashi-Kato, M.; Kitaura, Y.; Shimomura, Y.
Octanoic acid promotes branched-chain amino acid catabolisms via the inhibition of hepatic branched-chain alpha-keto acid dehydrogenase kinase in rats (2015), Metab. Clin. Exp., 64, 1157-1164.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	negligible inhibition by butanoic acid and dodecanoic acid	Rattus norvegicus
octanoic acid	-	Rattus norvegicus
trioctanoin	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]	Rattus norvegicus	-	ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q00972	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]	-	Rattus norvegicus	ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate	-	?

Synonyms

Synonyms	Comment	Organism
BCKDH kinase	-	Rattus norvegicus
BDK	-	Rattus norvegicus
branched-chain alpha-keto acid dehydrogenase kinase	-	Rattus norvegicus

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Release 2023.1 (January 2023)