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Literature summary for 2.7.11.4 extracted from
- Tissue-specific translation of murine branched-chain alpha-ketoacid dehydrogenase kinase mRNA is dependent upon an upstream open reading frame in the 5'-untranslated region (2004), J. Biol. Chem., 279, 44645-44655.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | tissue-specific translation of branched-chain alpha-ketoacid dehydrogenase kinase mRNA is dependent upon an upstream open reading frame in the 5'-untranslated region | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA sequence determination and analysis, promotor region footprinting, expression analysis, mechanism of the enzyme expression regulation | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase | Mus musculus | the catalyzed reversible specific phosphorylation of the BCKD subunit regulates the first committed step in the pathway for leucine, isoleucine, and valine catabolism | ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BNL CL.2 cell | liver cell line | Mus musculus | - |
| C2C12 cell | undifferentiated myoblast cell line | Mus musculus | - |
| fibroblast | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| additional information | tissue distribution, tissue-specific translation of branched-chain alpha-ketoacid dehydrogenase kinase mRNA is dependent upon an upstream open reading frame in the 5'-untranslated region, thus mRNA and protein level do not correlate | Mus musculus | - |
| myoblast | - |
Mus musculus | - |
| myotube | - |
Mus musculus | - |
| NIH-3T3 cell | fibroblast cell line | Mus musculus | - |
| skeletal muscle | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase | - |
Mus musculus | ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase | - |
? | |
| ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase | the catalyzed reversible specific phosphorylation of the BCKD subunit regulates the first committed step in the pathway for leucine, isoleucine, and valine catabolism | Mus musculus | ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BCKD kinase | - |
Mus musculus |
| branched-chain alpha-ketoacid dehydrogenase kinase | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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