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Literature summary for 2.7.11.4 extracted from

  • Paxton, R.; Harris, R.A.
    Regulation of branched-chain alpha-ketoacid dehydrogenase kinase (1984), Arch. Biochem. Biophys., 231, 48-57.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-Chloroisohexanoate
-
Oryctolagus cuniculus
2-oxo-3-methylpentanoate
-
Oryctolagus cuniculus
2-Oxohexanoate
-
Oryctolagus cuniculus
2-oxoisocaproate kinetics, 40% inhibition at 0.065 mM Oryctolagus cuniculus
2-oxoisopentanoate
-
Oryctolagus cuniculus
2-oxopentanoate kinetics Oryctolagus cuniculus
acetoacetyl-CoA 40% inhibition at 0.01 mM Oryctolagus cuniculus
heparin 40% inhibition at 0.012 mg/ml Oryctolagus cuniculus
isobutyryl-CoA
-
Oryctolagus cuniculus
isovaleryl-CoA
-
Oryctolagus cuniculus
malonyl-CoA
-
Oryctolagus cuniculus
methylmalonyl-CoA 40% inhibition at 0.2 mM Oryctolagus cuniculus
additional information no inhibition by acetate; no inhibition by acetyl-CoA; no inhibition by lactate; no inhibition by methylcrotonyl-CoA, beta-hydroxy-beta-methylglutaryl-CoA, crotonyl-CoA, octanoyl-CoA, succinyl-CoA, propionyl-CoA, 0.1 mM each, propionate, beta-hydroxybutyrate, acetoacetate, malonate, alpha-ketomalonate, succinate, citrate, oxaloacetate, FAD+, NADPH, 2 mM; no inhibition by NADH, NAD+ 1 mM each Oryctolagus cuniculus
n-Octanoate 40% inhibition at 0.5 mM Oryctolagus cuniculus
NADP+ 40% inhibition at 1.5 mM Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Oryctolagus cuniculus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]
-
Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Oryctolagus cuniculus