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Literature summary for 2.7.11.4 extracted from

  • Harris, R.A.; Kuntz, M.J.; Simpson, R.
    Inhibition of branched-chain alpha-keto acid dehydrogenase kinase by alpha-chloroisocaproate (1988), Methods Enzymol., 166, 114-123.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-Chloroisohexanoate no inhibition by (R)(-)-2-chloroisopentanoate; potassium phosphate increases sensitivity to this inhibitor Oryctolagus cuniculus
2-Chloroisohexanoate no inhibition by (R)(-)-2-chloroisopentanoate; potassium phosphate increases sensitivity to this inhibitor; (R)(+)-isomer is twice as effective as (S)(-)-isomer; site-specific inhibitor Rattus norvegicus
2-oxo-3-methylpentanoate more effective than 2-oxoisopentanoate Oryctolagus cuniculus
2-oxo-3-methylpentanoate more effective than 2-oxoisopentanoate Rattus norvegicus
2-oxoisocaproate more effective than 2-oxo-3-methylpentanoate and 2-oxoisopentanoate Oryctolagus cuniculus
2-oxoisocaproate more effective than 2-oxo-3-methylpentanoate and 2-oxoisopentanoate Rattus norvegicus
2-oxoisopentanoate less effective than 2-oxoisohexanoate and 2-oxo-3-methylpentanoate Oryctolagus cuniculus
2-oxoisopentanoate less effective than 2-oxoisohexanoate and 2-oxo-3-methylpentanoate Rattus norvegicus
Dichloroacetate weak Oryctolagus cuniculus
Dichloroacetate weak Rattus norvegicus
additional information no inhibition by 2-chloropropionate Oryctolagus cuniculus
additional information no inhibition by 2-chloropropionate Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Rattus norvegicus branched-chain amino acid metabolism ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Oryctolagus cuniculus branched-chain amino acid metabolism ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Rattus norvegicus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Oryctolagus cuniculus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
liver
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] 2 Ser-residues in E1-alpha-subunit Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] 2 Ser-residues in E1-alpha-subunit Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] branched-chain amino acid metabolism Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] branched-chain amino acid metabolism Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.5
-
2-Chloroisohexanoate 37°C Rattus norvegicus