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Literature summary for 2.7.11.31 extracted from

  • Noor, H.B.; Mou, N.A.; Salem, L.; Shimul, M.F.A.; Biswas, S.; Akther, R.; Khan, S.; Raihan, S.; Mohib, M.M.; Sagor, M.A.T.
    Anti-inflammatory property of AMP-activated protein kinase (2020), Antiinflamm. Antiallergy Agents Med. Chem., 19, 2-41 .
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
(5S)-3-[(13S)-13-hydroxy-14-(2-{[(2S)-2-hydroxydodecyl]oxy}ethoxy)tetradecyl]-5-methylfuran-2(5H)-one i.e. AA005 Mus musculus
5beta,19-epoxy-25-methoxy-cucurbita-6,23-diene-3beta,19-diol
-
 Mus musculus
A-769662
-
 Mus musculus
AICAR
-
 Mus musculus
astragalus polysaccharide extract
-
 Mus musculus
Baicalin
-
 Mus musculus
Berberine
-
 Mus musculus
black ginseng ethanol extract
-
 Mus musculus
capsaicin
-
 Mus musculus
CTRP1
-
 Mus musculus
cucurbitacin E
-
 Mus musculus
cyclocaric acid B
-
 Mus musculus
cyclocarioside H
-
 Mus musculus
dihydromyricetin
-
 Mus musculus
epigallocatechin 3-gallate
-
 Mus musculus
ETC-1002
-
 Mus musculus
ginsenoside Rb2
-
 Mus musculus
glabridin
-
 Mus musculus
imiquimod
-
 Mus musculus
liraglutide
-
 Mus musculus
mangiferin
-
 Mus musculus
naringin
-
 Mus musculus
oleuropein
-
 Mus musculus
pterostilbene
-
 Mus musculus
quercetin
-
 Mus musculus
resveratrol
-
 Mus musculus
thalidezine
-
 Mus musculus
TSC2-pS1387
-
 Mus musculus
yuja peel ethanol extract
-
 Mus musculus

Application

Application Comment Organism
medicine the enzyme can be an alternative therapeutic approach to preventing and managing obesity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + JAK1 Mus musculus phosphorylation at Ser515 and Ser518 ADP + phosphorylated JAK1
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein protein kinase B increases the phosphorylation of AMPKalpha1 subunit at Ser485/Ser491, which subsequently prevents the phosphorylation of the enzyme at Thr172 by liver kinase B1 and thus suppresses the activation of the enzyme Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Mus musculus
-
carcinoma cell
-
 Mus musculus
-
cardiac muscle fiber
-
 Mus musculus
-
endothelial cell
-
 Mus musculus
-
glioma cell
-
 Mus musculus
-
hepatocyte
-
 Mus musculus
-
macrophage
-
 Mus musculus
-
microglia
-
 Mus musculus
-
smooth muscle cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + JAK1 phosphorylation at Ser515 and Ser518 Mus musculus ADP + phosphorylated JAK1
-
 ?

Synonyms

Synonyms Comment Organism
adenosine monophosphate-activated protein kinase
-
 Mus musculus
AMP-activated protein kinase
-
 Mus musculus
AMPK
-
 Mus musculus

General Information

General Information Comment Organism
metabolism blood glucose might be controlled by enzyme activation Mus musculus
physiological function once activated, the enzyme suppresses the necessary enzymes involved in ATP-consuming anabolic pathways and enhances cellular ATP supply. Enzyme activation can facilitate bacterial eradication in sepsis and related inflammatory conditions associated with the inhibition of neutrophil activation and chemotaxis. The enzyme also inhibits nuclear factor-kappaB signaling and inflammation Mus musculus