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Literature summary for 2.7.11.31 extracted from
- Sex-specific regulation of AMP-activated protein kinase (AMPK) in the Pacific oyster Crassostrea gigas (2013), Biol. Reprod., 89, 100.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA and amino acid sequence determination and analysis, phylogenetic tree, real-time PCR expression analysis of the AMPK alpha, beta, and gamma subunits, overview | Crassostrea gigas |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
- |
Crassostrea gigas |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Crassostrea gigas | J7H7T6 | - |
- |
| Crassostrea gigas | K1R1Z4 | - |
- |
| Crassostrea gigas | T1R3F6 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| lipoprotein | the subunit beta sequence contains an N-myristoylation site | Crassostrea gigas |
| phosphoprotein | phosphorylation of the catalytic AMPK alpha protein at threonine 172 | Crassostrea gigas |
| phosphoprotein | serine 108 and serine 182 phosphorylation sites in subunit beta | Crassostrea gigas |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gonad | of female and male oysters, expression of AMP-activated protein kinase (AMPK) subunits during gametogenesis in the gonad, overview. AMPK beta transcripts in the gonad at different reproductive stages decrease from stage 1 to 3 | Crassostrea gigas | - |
| gonad | of female and male oysters, expression of AMP-activated protein kinase (AMPK) subunits during gametogenesis in the gonad, overview. AMPK gamma transcripts amounts in the gonad at different reproductive stages are quit constant | Crassostrea gigas | - |
| gonad | of female and male oysters, expression of AMP-activated protein kinase (AMPK) subunits during gametogenesis in the gonad, overview. Subunit AMPK alpha mRNA levels are more abundant in males at the first stage of gametogenesis, when mitotic activity and the differentiation of germinal cells occur, and are always more abundant in males than in females. AMPKalpha Thr172 phosphorylation appears to be almost totally inhibited in mature female gonads at stage 3, at the time when accumulation of reserves in oocytes is promoted, while it remains at a high level in mature spermatozoa. Truncated (45-kDa) and entire (62-kDa) AMPK alpha proteins are detected in gonads of both males and females at all reproductive stages. In both males and females, AMPK alpha truncated protein is detected at a very low level, and its amount does not vary significantly during reproduction, while the entire AMPK alpha protein is detected at a high level, and its amount varies significantly during reproduction. AMPK alpha transcripts in the gonad at different reproductive stages decreases from stage 1 to 3 | Crassostrea gigas | - |
| additional information | activity status of AMPK in the gonadic tissue of male and female oysters reared under natural conditions | Crassostrea gigas | - |
| oocyte | - |
Crassostrea gigas | - |
| spermatozoon | - |
Crassostrea gigas | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 60000, alpha-subunit, SDS-PAGE | Crassostrea gigas |
| heterotrimer | AMPK is a heterotrimeric kinase composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma | Crassostrea gigas |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AMP-activated protein kinase | - |
Crassostrea gigas |
| AMPK | - |
Crassostrea gigas |
| AMPKalpha | - |
Crassostrea gigas |
| AMPKbeta | - |
Crassostrea gigas |
| AMPKgamma | - |
Crassostrea gigas |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | the genes encoding the three subunits of AMPK are highly conserved in eukaryotic species for which complete genome sequences are available, including vertebrates, invertebrates, plants, fungi, and protozoa | Crassostrea gigas |
| physiological function | sex-specific regulation of AMP-activated protein kinase alpha in the Pacific oyster Crassostrea gigas. AMPKalpha activation might play a sex-dependent role in management of energy during gametogenesis in oyster | Crassostrea gigas |
| physiological function | sex-specific regulation of AMP-activated protein kinase in the Pacific oyster Crassostrea gigas | Crassostrea gigas |
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