Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.31 extracted from

  • Thali, R.F.; Tuerk, R.D.; Scholz, R.; Yoho-Auchli, Y.; Brunisholz, R.A.; Neumann, D.
    Novel candidate substrates of AMP-activated protein kinase identified in red blood cell lysates (2010), Biochem. Biophys. Res. Commun., 398, 296-301.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
AMP
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13131
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein autophosphorylation of 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-mercaptopyruvate sulfurtransferase
-
 Homo sapiens ADP + phosphorylated 3-mercaptopyruvate sulfurtransferase
-
 ?
ATP + acylamino-acid-releasing enzyme
-
 Homo sapiens ADP + phosphorylated acylamino-acid-releasing enzyme
-
 ?
ATP + adenylate kinase isoenzyme 1
-
 Homo sapiens ADP + phosphorylated adenylate kinase isoenzyme 1
-
 ?
ATP + band 3 anion transport protein
-
 Homo sapiens ADP + phosphorylated band 3 anion transport protein
-
 ?
ATP + beta actin
-
 Homo sapiens ADP + phosphorylated beta actin
-
 ?
ATP + bisphosphoglycerate mutase
-
 Homo sapiens ADP + phosphorylated bisphosphoglycerate mutase
-
 ?
ATP + carbonic anhydrase 1
-
 Homo sapiens ADP + phosphorylated carbonic anhydrase 1
-
 ?
ATP + catalase
-
 Homo sapiens ADP + phosphorylated catalase
-
 ?
ATP + cytoplasmic malate dehydrogenase
-
 Homo sapiens ADP + phosphorylated cytoplasmic malate dehydrogenase
-
 ?
ATP + dihydropteridine reductase
-
 Homo sapiens ADP + phosphorylated dihydropteridine reductase
-
 ?
ATP + DNA damage-binding protein 1
-
 Homo sapiens ADP + phosphorylated DNA damage-binding protein 1
-
 ?
ATP + erythrocyte spectrin alpha chain
-
 Homo sapiens ADP + phosphorylated erythrocyte spectrin alpha chain
-
 ?
ATP + erythrocyte spectrin beta chain
-
 Homo sapiens ADP + phosphorylated erythrocyte spectrin beta chain
-
 ?
ATP + flavin reductase
-
 Homo sapiens ADP + phosphorylated flavin reductase
-
 ?
ATP + glutathione S-transferase omega-1
-
 Homo sapiens ADP + phosphorylated glutathione S-transferase omega-1
-
 ?
ATP + glutathione synthetase
-
 Homo sapiens ADP + phosphorylated glutathione synthetase
-
 ?
ATP + peroxiredoxin-2
-
 Homo sapiens ADP + phosphorylated peroxiredoxin-2
-
 ?
ATP + peroxiredoxin-6
-
 Homo sapiens ADP + phosphorylated peroxiredoxin-6
-
 ?
ATP + phosphoglycerate kinase 1
-
 Homo sapiens ADP + phosphorylated phosphoglycerate kinase 1
-
 ?
ATP + phosphoribosylformylglycinamidine synthase
-
 Homo sapiens ADP + phosphorylated phosphoribosylformylglycinamidine synthase
-
 ?
ATP + proteasome subunit alpha type-1
-
 Homo sapiens ADP + phosphorylated proteasome subunit alpha type-1
-
 ?
ATP + proteasome subunit alpha type-7
-
 Homo sapiens ADP + phosphorylated proteasome subunit alpha type-7
-
 ?
ATP + purine nucleoside phosphorylase
-
 Homo sapiens ADP + phosphorylated purine nucleoside phosphorylase
-
 ?
ATP + S-formylglutathione hydrolase
-
 Homo sapiens ADP + phosphorylated S-formylglutathione hydrolase
-
 ?
ATP + selenium binding protein 1
-
 Homo sapiens ADP + phosphorylated selenium binding protein 1
-
 ?
ATP + thioredoxin-like protein 1
-
 Homo sapiens ADP + phosphorylated thioredoxin-like protein 1
-
 ?
ATP + transaldolase
-
 Homo sapiens ADP + phosphorylated transaldolase
-
 ?
ATP + transferrin
-
 Homo sapiens ADP + phosphorylated transferrin
-
 ?
ATP + ubiquitin carboxyl-terminal hydrolase 13
-
 Homo sapiens ADP + phosphorylated ubiquitin carboxyl-terminal hydrolase 13
-
 ?
ATP + ubiquitin carboxyl-terminal hydrolase 14
-
 Homo sapiens ADP + phosphorylated ubiquitin carboxyl-terminal hydrolase 14
-
 ?
ATP + ubiquitin carboxyl-terminal hydrolase 5
-
 Homo sapiens ADP + phosphorylated ubiquitin carboxyl-terminal hydrolase 5
-
 ?
ATP + ubiquitin-activating enzyme E1
-
 Homo sapiens ADP + phosphorylated ubiquitin-activating enzyme E1
-
 ?
ATP + valosin-containing protein
-
 Homo sapiens ADP + phosphorylated valosin-containing protein
-
 ?
additional information identification of putative AMPK targets in hemoglobin-depleted lysates of erythrocytes, including metabolic enzymes, cytoskeletal proteins and enzymes involved in the oxidative stress response, cloning and recombinant expression Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
5'-AMP-activated protein kinase catalytic subunit alpha-1
-
 Homo sapiens
AMP-activated protein kinase
-
 Homo sapiens
AMPK
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the absence of functional AMPK may consequently cause a failure of distinct signaling pathways in red bood cells Homo sapiens
physiological function AMPK is a metabolic stress-sensing kinase with important functions for red blood cell survival. Identification of putative AMPK targets in hemoglobin-depleted lysates of erythrocytes, including metabolic enzymes, cytoskeletal proteins and enzymes involved in the oxidative stress response, cloning and recombinant expression. AMPK aids the function of red blood cells Homo sapiens