Literature summary for 2.7.11.31 extracted from

Hien, T.T.; Kim, H.G.; Han, E.H.; Kang, K.W.; Jeong, H.G.
Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells (2010), Mol. Nutr. Food Res., 54, 918-928.

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Activating Compound

Activating Compound	Comment	Organism	Structure
puerarin	stimulates AMPK, puerarin down-regulated MDR1 expression via nuclear factor kappa-B and cAMP-responsive element transcriptional activity-dependent up-regulation of AMPK in MCF-7/adr cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine	compound C, AMPK inhibitor, reduces puerarin-induced suppression of MDR1 expression	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	MCF-7/adr cell	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
AMP-activated protein kinase	-	Homo sapiens
AMPK	-	Homo sapiens

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Release 2023.1 (January 2023)