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Literature summary for 2.7.11.31 extracted from

  • Scharl, M.; Paul, G.; Barrett, K.E.; McCole, D.F.
    AMP-activated protein kinase mediates the interferon-gamma-induced decrease in intestinal epithelial barrier function (2009), J. Biol. Chem., 284, 27952-27963.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
IFNgamma activates AMPK by phosphorylation of Thr172, independent of intracellular energy (ATP) levels. Phosphatidylinositol 3'-kinase inhibition by LY294002 partially prevents IFNgamma-induced activation of AMPK Homo sapiens

Application

Application Comment Organism
medicine implication of AMPK in the pathogenesis of chronic intestinal inflammatory conditions, such as inflammatory bowel disease Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine compound C, inhibition of AMPK prevents at 0.05 mM, in part, the IFNgamma-induced decrease in transepithelial electrical resistance, the increased epithelial permeability, the decreased transepithelial electrical resistance, and the decrease in occludin and zonula occludens-1 caused by IFNgamma treatment of T84 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-84 cell intestinal epithelial cell Homo sapiens
-

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Homo sapiens
AMPK
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens siRNA knockdown of AMPK, which ameliorates the IFNgamma-induced increase in epithelial permeability and decrease in transepithelial electrical resistance down

General Information

General Information Comment Organism
physiological function role for AMPK, in concert with other signals induced by IFNgamma, in mediating reduced epithelial barrier function in a cell model of chronic intestinal inflammation Homo sapiens