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Literature summary for 2.7.11.31 extracted from

  • Cheng, H.L.; Huang, H.K.; Chang, C.I.; Tsai, C.P.; Chou, C.H.
    A cell-based screening identifies compounds from the stem of Momordica charantia that overcome insulin resistance and activate AMP-activated protein kinase (2008), J. Agric. Food Chem., 56, 6835-6843.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
(23E)-cucurbita-5,23,25-triene-3beta,7beta-diol CH10, triterpene from the stem of bitter melon Momordica charantia, leads to the activation of AMPK in cells, overcomes insulin resistance Mus musculus
3beta,25-dihydroxy-7beta-methoxycucurbita-5,23(E)-diene CH63, triterpene from the stem of bitter melon Momordica charantia, leads to the activation of AMPK in cells, overcomes insulin resistance Mus musculus
3beta,7beta,25-trihydroxycucurbita-5,23(E)-dien-19-al CH93, triterpene from the stem of bitter melon Momordica charantia, leads to the activation of AMPK in cells, overcomes insulin resistance Mus musculus
additional information methanol extracts from the fruit, seed, or stem of bitter melon Momordica charantia all contain components efficacious in improving glucose uptake of insulin-resistant cells involving activation of AMPK Mus musculus

Application

Application Comment Organism
drug development triterpenoids are potential hypoglycemic components of the plant and the mechanism underlying their action involves AMPK Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
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 Mus musculus
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FL83B cell
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 Mus musculus
-

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Mus musculus
AMPK
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 Mus musculus