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Literature summary for 2.7.11.31 extracted from

  • Beck Jorgensen, S.; ONeill, H.M.; Hewitt, K.; Kemp, B.E.; Steinberg, G.R.
    Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity (2009), Diabetologia, 52, 2395-2404.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside AICAR, activating phosphorylation of alphaAMPK T172 in response to AICAR increases normally in muscle from obese mice fed a high-fat diet Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male C57/BL6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
extensor digitorum longus
-
 Mus musculus
-
gastrocnemius
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-
soleus
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Mus musculus
AMPK
-
 Mus musculus

General Information

General Information Comment Organism
physiological function transgenic littermates overexpressing an alpha2AMPK kinase-dead (KD) have reduced skeletal muscle alpha2AMPK activity (50% in gastrocnemius and more than 80% in soleus and extensor digitorum longus) and acetyl-CoA carboxylase-2 Ser228 phosphorylation (90% in gastrocnemius). Obesity in response to high-fat feeding is not associated with impaired AMPK actions, obesity-induced lipid accumulation and insulin resistance are not exacerbated in AMPK KD mice Mus musculus