Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-aminoimidazole-4-carboxamide riboside | AICAR, increases phosphorylation of alpha1 AMPK, resulting in inactivation of ACCalpha in MAC-T cells | Bos taurus | |
additional information | decreases in energy availability or rises in intracellular Ca2+ most likely activates AMPK in MAC-T cell | Bos taurus |
Application | Comment | Organism |
---|---|---|
industry | AMPK as a molecular target capable of modifying energy substrate utilization may result in the development of new technologies that increase milk production or modify milk composition during periods of increased energy demand | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose | bull, presence of alpha, beta, and gamma isoforms of AMPK | Bos taurus | - |
liver | bull, presence of alpha, beta, and gamma isoforms of AMPK | Bos taurus | - |
mammary epithelial cell | MAC-T cells from Holstein and Jersey cows | Bos taurus | - |
mammary gland | - |
Bos taurus | - |
muscle | bull, presence of alpha, beta, and gamma isoforms of AMPK | Bos taurus | - |
Synonyms | Comment | Organism |
---|---|---|
AMP-activated protein kinase | - |
Bos taurus |
AMPK | - |
Bos taurus |
Organism | Comment | Expression |
---|---|---|
Bos taurus | relative expression of alpha, beta, and gamma isoforms of AMPK is greatest in muscle and MAC-T cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | AMPK activation dramatically decreases de novo fatty acid synthesis and inactivates ACCalpha. AMPK activation modifies lipogenic gene expression including fatty acid synthase, glycerol-3-phosphate acyltransferase, and fatty acid binding protein-3. AMPK is able to inhibit fatty acid synthesis, an energy consuming process, in response to decreases in energy supply | Bos taurus |