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Literature summary for 2.7.11.31 extracted from

  • Zhu, M.J.; Han, B.; Tong, J.; Ma, C.; Kimzey, J.M.; Underwood, K.R.; Xiao, Y.; Hess, B.W.; Ford, S.P.; Nathanielsz, P.W.; Du, M.
    AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep (2008), J. Physiol., 586, 2651-2664.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
AMP
-
 Ovis aries
additional information phosphorylation of AMPK at Thr172 of the alpha-subunit activates the enzyme Ovis aries

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [acetyl-CoA carboxylase] Ovis aries phosphorylation at Ser79 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
additional information Ovis aries AMPK signalling pathways are downregulated and skeletal muscle development is impaired in fetuses of obese, over-nourished sheep without differences in energy status, i.e. the AMP/ATP ratio, overview. Decreased signalling of the AMPK system in skeletal muscle of fetuses of OB mothers may play a role in altered muscle development and development of insulin resistance in the offspring ?
-
 ?

Organism

Organism UniProt Comment Textmining
Ovis aries
-
 obese ewes
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of AMPK at Thr172 of the alpha-subunit Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
fetus
-
 Ovis aries
-
skeletal muscle fetal, semitendinosus Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [acetyl-CoA carboxylase] phosphorylation at Ser79 Ovis aries ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
additional information AMPK signalling pathways are downregulated and skeletal muscle development is impaired in fetuses of obese, over-nourished sheep without differences in energy status, i.e. the AMP/ATP ratio, overview. Decreased signalling of the AMPK system in skeletal muscle of fetuses of OB mothers may play a role in altered muscle development and development of insulin resistance in the offspring Ovis aries ?
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Ovis aries
AMPK
-
 Ovis aries

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Ovis aries