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Literature summary for 2.7.11.31 extracted from

  • Miyamoto, T.; Oshiro, N.; Yoshino, K.; Nakashima, A.; Eguchi, S.; Takahashi, M.; Ono, Y.; Kikkawa, U.; Yonezawa, K.
    AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus (2008), J. Biol. Chem., 283, 4430-4438.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
2-deoxyglucose blocks glucose utilization and increases the intracellular AMP concentration, activation is suppressed by compound C Homo sapiens
5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside i.e. AICAR, an AMP-activated protein kinase specific activator Homo sapiens
AMP
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-fused constitutively active form of AMPK alpha1, residues 1-312, and of the kinase-dead mutant AMPK in HEK-193 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of the kinase-negative AMPK inhibits enzyme activation by 2-deoxyglucose Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
compound C
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [Golgi-specific brefeldin A resistance factor 1] Homo sapiens phosphorylation at Thr1337 to induce disassembly of Golgi apparatus ADP + [Golgi-specific brefeldin A resistance factor 1] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [Golgi-specific brefeldin A resistance factor 1] phosphorylation at Thr1337 to induce disassembly of Golgi apparatus Homo sapiens ADP + [Golgi-specific brefeldin A resistance factor 1] phosphate
-
 ?
ATP + [Golgi-specific brefeldin A resistance factor 1] a guanine nucleotide exchange factor for the ADP-ribosylation factor family associated with the Golgi apparatus, phosphorylation at Thr1337, phosphorylation site identification by mutational analysis Homo sapiens ADP + [Golgi-specific brefeldin A resistance factor 1] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Homo sapiens
AMPK
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens