Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | AMP-binding to AMPK inhibits dephosphorylation at Thr172 | Homo sapiens | |
additional information | activation of AMPK requires phosphorylation at Thr172 by an AMPK kinases, e.g. LKB1 and Ca2+/calmodulin-dependent kinase kinase, CaMKK | Homo sapiens | |
rosiglitazone | stimulates an increase in the ADP/ATP ratio and AMPK activity essentially involving LKB1 and leading to activation of nitric oxide synthesis in human aortic endothelial cells, the stimulation of AMPK and NO synthesis by rosiglitazone is unaffected by the peroxisome proliferator-activated receptor-gamma inhibitor GW9662 or by STO-609, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant enzyme in human aortic endothelial cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a dominant negative AMP-activated protein kinase mutant abrogates rosiglitazone-stimulated Ser1177 phosphorylation and NO production in endothelial cells | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [endothelial nitic oxide synthase] | Homo sapiens | activates nitric oxide synthesis, mechanism, overview | ADP + [endothelial nitic oxide synthase] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | activation of AMPK requires phosphorylation at Thr172 by an AMPK kinases, e.g. LKB1 and Ca2+/calmodulin-dependent kinase kinase, CaMKK | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Homo sapiens | - |
endothelial cell | human umbilical vein endothelial cell, HUVEC | Homo sapiens | - |
HeLa cell | HeLa cells stably expressing wild type LKB1 or a kinase-inactive mutant LKB1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [endothelial nitic oxide synthase] | activates nitric oxide synthesis, mechanism, overview | Homo sapiens | ADP + [endothelial nitic oxide synthase] phosphate | - |
? | |
ATP + [endothelial nitic oxide synthase] | phosphorylation by AMPK at Ser1177 | Homo sapiens | ADP + [endothelial nitic oxide synthase] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AMP-activated protein kinase | - |
Homo sapiens |
AMPK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |