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Literature summary for 2.7.11.31 extracted from

  • Long, Y.C.; Zierath, J.R.
    Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle (2008), Am. J. Physiol. Endocrinol. Metab., 295, E545-E552.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
AMP
-
 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of AMPKgamma3-knockout mice, which show impaired fasting-induced expression of skeletal musclelipid oxidative genes, while in mice overexpressing AMPKgamma3, an upregulation of lipid metabolic and mitochondrial gene expression occurs, overexpression or deletion of AMPKalpha2 subunit leads to abolishment of mitochondrial gene expression activation Mus musculus
R225Q the mutation in gamma3 subunit leads to enhanced expression of Cd36 and cytochrome c in transgenic mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information calcineurin blocks AMPKgamma3 subunit expression Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus AMPK and calcineurin, a calcium-regulated serine/threonine protein phosphatase, regulate skeletal muscle metabolic gene expression programs in response to changes in the energy status and levels of neuronic input, respectively. AMPK activates metabolic genes, mitochondrial biogenesis, glucose uptake, lipid oxidation, and insulin sesitivity, but blocks protein synthesis, pathway and regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
neuron
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information AMPK and calcineurin, a calcium-regulated serine/threonine protein phosphatase, regulate skeletal muscle metabolic gene expression programs in response to changes in the energy status and levels of neuronic input, respectively. AMPK activates metabolic genes, mitochondrial biogenesis, glucose uptake, lipid oxidation, and insulin sesitivity, but blocks protein synthesis, pathway and regulation, overview Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
trimer alphabetagamma heterotrimer composed of different alpha, beta, and gamma subunit variants Mus musculus

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Mus musculus
AMPK
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus