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Literature summary for 2.7.11.31 extracted from

  • Winder, W.W.; Hardie, D.G.
    AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes (1999), Am. J. Physiol., 277, E1-10.
    View publication on PubMed
Search for more literature for 2.7.11.31

Application

Application Comment Organism
medicine defects or disuse of the AMPK signaling system would be predicted to result in many of the metabolic perturbations observed in type 2 diabetes mellitus Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA carboxylase
-
 Homo sapiens ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + adipose hormone-sensitive lipase
-
 Homo sapiens ADP + adipose hormone-sensitive lipase phosphate
-
 ?
additional information phosphorylates key target proteins that control flux through metabolic pathways of hepatic ketogenesis, cholesterol synthesis, adipocyte lipolysis and skeletal muscle fatty acid oxidation Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
heterotrimer
-
 Homo sapiens