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Literature summary for 2.7.11.31 extracted from

  • Wang, W.; Yang, X.; Lopez de Silanes, I.; Carling, D.; Gorospe, M.
    Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function (2003), J. Biol. Chem., 278, 27016-27023.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
5'-AMP
-
 Homo sapiens
5-amino-4-imidazolecarboxamide ribotide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Homo sapiens
-
 IDH4, IMr90 and WI38 fibroblasts
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-
IDH4 cell
-
 Homo sapiens
-
IMR-90 cell
-
 Homo sapiens
-
WI-38 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNA-binding protein HUR inhibits the protein by phosphorylation Homo sapiens ADP + ?
-
 ?
additional information conditions that elevate the AMP:ATP ratio in cells, such as growth factor depletion, hypoglycemia, ischemia in heart muscle, exercise in skeletal muscle, as well as treatment with arsenite, azide, oxidative agents and the pharmacological agent AICAR, which mimics the effect of AMP can cause activation of AMPK Homo sapiens ?
-
 ?