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Literature summary for 2.7.11.30 extracted from

  • Li, L.; Zhao, X.Y.; Wang, B.E.
    Down-regulation of transforming growth factor beta 1/activin receptor-like kinase 1 pathway gene expression by herbal compound 861 is related to deactivation of LX-2 cells (2008), World J. Gastroenterol., 14, 2894-2899.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
LX-2 cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
activin receptor-like kinase 1
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Homo sapiens
ALK1
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens down-regulation of ALK1 in LX-2 cells by the herbal compound Cpd861, cells are treated with TGF-beta1 (5 ng/ml) Cpd861 (0.1 mg/ml), TGF-beta1 (5 ng/ml) plus Cpd861 (an extract of 10 herbs traditionally applied as chinese medicine, 5 ng/ml) for 24 h to investigate the effect of Cpd861 on the TGF-beta1/ALK1 pathway down
Homo sapiens the ALK1 gene is constitutively expressed in LX-2 cells and TGF-beta1 does not further increase its expression additional information