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Literature summary for 2.7.11.30 extracted from
- Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells (2009), J. Biol. Chem., 284, 15794-15804.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| SD-208 | selektive ALK5 kinase inhibitor | Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 65000 | - |
ALK1 protein, determined by SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pulmonary artery endothelial cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| activin-like kinase receptor 1 | - |
Homo sapiens |
| ALK1 | - |
Homo sapiens |
| BMPR-II | - |
Homo sapiens |
| bone morphogenetic protein type II receptor | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | reduction of endogenous ALK1 expression significantly attenuates BMP9-mediated phosphorylation of Smad1/5 and Smad2 | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | mutations in transforming growth factor-beta (TGF-beta) receptor superfamily members underlie conditions characterized by vascular dysplasia | Homo sapiens |
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Release 2023.1 (January 2023)
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