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Literature summary for 2.7.11.30 extracted from
- TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines (2003), Oncogene, 22, 1317-1323.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| TGF-beta | activates the TGF-beta receptor by direct binding | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Smad2 | Homo sapiens | TGF-beta-mediated activation of Smad2 by the TGF-beta receptor | ADP + phosphorylated Smad2 | - |
? |  |
| ATP + Smad3 | Homo sapiens | TGF-beta-mediated activation of Smad3 by the TGF-beta receptor | ADP + phosphorylated Smad3 | - |
? | |
| additional information | Homo sapiens | in TGF-beta signaling, phosphorylated Smad2 and Smad3 form a complex with tumor suppressor Smad4, the complex is translocated to the nucleus, nuclear translocation of Smad2 and Smad3 in absence of Smad4 is not sufficient for TGF-beta-induced transcriptional responses, Smad4 mutations occur in some human cancers and inactivate the TGF-beta signaling, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BxPC-3 cell | pancreatic Smad4 null cell line, expression of Smad2 and Smad3 | Homo sapiens | - |
| CFPAC-1 cell | pancreatic Smad4 null cell line, expression of Smad2 and Smad3 | Homo sapiens | - |
| HS-766T cell | pancreatic Smad4 null cell line, expression of Smad2 and Smad3 | Homo sapiens | - |
| MDA-MB-468 cell | breast Smad4 null cell line, expression of Smad2 and Smad3 | Homo sapiens | - |
| VACO cell | diverse VACO cell lines, Smad4 null cell lines, expression analysis of Smad2, overview | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Smad2 | TGF-beta-mediated activation of Smad2 by the TGF-beta receptor | Homo sapiens | ADP + phosphorylated Smad2 | - |
? | |
| ATP + Smad2 | the substrate is a tumor suppressor | Homo sapiens | ADP + phosphorylated Smad2 | - |
? | |
| ATP + Smad3 | TGF-beta-mediated activation of Smad3 by the TGF-beta receptor | Homo sapiens | ADP + phosphorylated Smad3 | - |
? | |
| ATP + Smad3 | the substrate is a tumor suppressor | Homo sapiens | ADP + phosphorylated Smad3 | - |
? | |
| additional information | in TGF-beta signaling, phosphorylated Smad2 and Smad3 form a complex with tumor suppressor Smad4, the complex is translocated to the nucleus, nuclear translocation of Smad2 and Smad3 in absence of Smad4 is not sufficient for TGF-beta-induced transcriptional responses, Smad4 mutations occur in some human cancers and inactivate the TGF-beta signaling, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TGF-beta receptor | - |
Homo sapiens |
| transforming growth factor-beta receptor | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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