Activating Compound | Comment | Organism | Structure |
---|---|---|---|
TGF-beta | - |
Gallus gallus |
Cloned (Comment) | Organism |
---|---|
transient expression of ALK2 and ALK5 in C3H10T1/2 cells using the adenovirus transfection system | Gallus gallus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | misexpression of ALK2 in nontransforming ventricular, endocardial cells causes epithelial-mesenchymal transformation, EMT, which can be decreased by overexpression of inhibitor Smad6 | Gallus gallus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Gallus gallus | TGF-beta signals via its receptor type I and type II, ALK5 mediates most of the TGF-beta signaling, misexpression of ALK2, being constitutively active, in nontransforming ventricular, endocardial cells causes epithelial-mesenchymal transformation, EMT, which can be inhibited by Smad6, since ALK2 alone is sufficient to cause EMT, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endocardium | ALK2, nontransforming ventricular, misexpression of LAK2 in endocardial cells | Gallus gallus | - |
epithelium | - |
Gallus gallus | - |
heart | ALK2 and ALK5, atrioventricular cushion of developing heart | Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | TGF-beta signals via its receptor type I and type II, ALK5 mediates most of the TGF-beta signaling, misexpression of ALK2, being constitutively active, in nontransforming ventricular, endocardial cells causes epithelial-mesenchymal transformation, EMT, which can be inhibited by Smad6, since ALK2 alone is sufficient to cause EMT, overview | Gallus gallus | ? | - |
? | |
additional information | ALK2 and ALK5 are type I receptors | Gallus gallus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
activin receptor-like kinase 2 | - |
Gallus gallus |
activin receptor-like kinase 5 | - |
Gallus gallus |
ALK2 | - |
Gallus gallus |
ALK5 | - |
Gallus gallus |
TGF-beta receptor I | - |
Gallus gallus |
TGF-beta receptor II | - |
Gallus gallus |
transforming growth factor-beta receptor I | - |
Gallus gallus |
transforming growth factor-beta receptor II | - |
Gallus gallus |