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Literature summary for 2.7.11.30 extracted from

  • Desgrosellier, J.S.; Mundell, N.A.; McDonnell, M.A.; Moses, H.L.; Barnett, J.V.
    Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation (2005), Dev. Biol., 280, 201-210.
    View publication on PubMed
Search for more literature for 2.7.11.30

Activating Compound

Activating Compound Comment Organism Structure
TGF-beta
-
 Gallus gallus

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of ALK2 and ALK5 in C3H10T1/2 cells using the adenovirus transfection system Gallus gallus

Protein Variants

Protein Variants Comment Organism
additional information misexpression of ALK2 in nontransforming ventricular, endocardial cells causes epithelial-mesenchymal transformation, EMT, which can be decreased by overexpression of inhibitor Smad6 Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Gallus gallus TGF-beta signals via its receptor type I and type II, ALK5 mediates most of the TGF-beta signaling, misexpression of ALK2, being constitutively active, in nontransforming ventricular, endocardial cells causes epithelial-mesenchymal transformation, EMT, which can be inhibited by Smad6, since ALK2 alone is sufficient to cause EMT, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endocardium ALK2, nontransforming ventricular, misexpression of LAK2 in endocardial cells Gallus gallus
-
epithelium
-
 Gallus gallus
-
heart ALK2 and ALK5, atrioventricular cushion of developing heart Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information TGF-beta signals via its receptor type I and type II, ALK5 mediates most of the TGF-beta signaling, misexpression of ALK2, being constitutively active, in nontransforming ventricular, endocardial cells causes epithelial-mesenchymal transformation, EMT, which can be inhibited by Smad6, since ALK2 alone is sufficient to cause EMT, overview Gallus gallus ?
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 ?
additional information ALK2 and ALK5 are type I receptors Gallus gallus ?
-
 ?

Synonyms

Synonyms Comment Organism
activin receptor-like kinase 2
-
 Gallus gallus
activin receptor-like kinase 5
-
 Gallus gallus
ALK2
-
 Gallus gallus
ALK5
-
 Gallus gallus
TGF-beta receptor I
-
 Gallus gallus
TGF-beta receptor II
-
 Gallus gallus
transforming growth factor-beta receptor I
-
 Gallus gallus
transforming growth factor-beta receptor II
-
 Gallus gallus