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Literature summary for 2.7.11.30 extracted from

  • Ge, R.; Rajeev, V.; Subramanian, G.; Reiss, K.A.; Liu, D.; Higgins, L.; Joly, A.; Dugar, S.; Chakravarty, J.; Henson, M.; McEnroe, G.; Schreiner, G.; Reiss, M.
    Selective inhibitors of type I receptor kinase block cellular transforming growth factor-beta signaling (2004), Biochem. Pharmacol., 68, 41-50.
    View publication on PubMed
Search for more literature for 2.7.11.30

Activating Compound

Activating Compound Comment Organism Structure
actividin activates Smad2 phosphorylation via type I receptor kinases Homo sapiens
TGF-beta i.e. transforming growth factor-beta, interacts with and activates type I transforming growth factor-beta receptor Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
functional co-expression of TGF-beta and the soluble intracellular domain of the TGF-beta type I receptor in murine mammary gland epithelial cells and in mink lung epithelial cells inducing growth inhibition Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information functional co-expression of TGF-beta and the soluble intracellular domain of the TGF-beta type I receptor in murine mammary gland epithelial cells induces transdifferentiation of epithelial cells to mesenchymal cells, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Smad2 Homo sapiens TGF-beta- or actividin-induced phosphorylation ADP + phosphorylated Smad2
-
 ?
additional information Homo sapiens TGF-beta is responsible for induction of growth arrest in cells via the transforming growth factor-beta receptor I, the inhibition can be blocked by cell treatment with SD-093overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast carcinoma cell
-
 Homo sapiens
-
MDA-MB-231 cell breast carcinoma cell line, derived from malignant pleural effusions Homo sapiens
-
MDA-MB-435 cell breast carcinoma cell line, derived from malignant pleural effusions Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Smad2 TGF-beta- or actividin-induced phosphorylation Homo sapiens ADP + phosphorylated Smad2
-
 ?
ATP + Smad2 recombinant GST-fusion Smad2 substrate expressed in Escherichia coli, TGF-beta- or actividin-induced phosphorylation of the two C-terminal Ser residues in the Ser-Ser-Xaa-Ser motif Homo sapiens ADP + phosphorylated Smad2
-
 ?
additional information TGF-beta is responsible for induction of growth arrest in cells via the transforming growth factor-beta receptor I, the inhibition can be blocked by cell treatment with SD-093overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TbetaKI
-
 Homo sapiens
TGF-beta receptor I
-
 Homo sapiens
transforming growth factor-beta receptor I
-
 Homo sapiens
type I receptor kinase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens