Literature summary for 2.7.11.3 extracted from

Hawley, S.A.; Davison, M.; Woods, A.; Davies, S.P.; Beri, R.K.; Carling, D.; Hardie, D.G.
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase (1996), J. Biol. Chem., 271, 27879-27887.

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Activating Compound

Activating Compound	Comment	Organism	Structure
5'-AMP	-	Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
58000	-	? * 58000 + ?, catalytic alpha subunit, SDS-PAGE	Rattus norvegicus
196000	-	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]	Rattus norvegicus	phosphorylation activates EC 2.7.1.109	ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partial	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
101	-	-	Rattus norvegicus

Storage Stability

Storage Stability	Organism
-20°C, can be stored in buffer containing 50% glycerol for up to a month	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]	-	Rattus norvegicus	ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]	-	?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]	phosphorylation activates EC 2.7.1.109	Rattus norvegicus	ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]	-	?

Subunits

Subunits	Comment	Organism
?	? * 58000 + ?, catalytic alpha subunit, SDS-PAGE	Rattus norvegicus

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Release 2023.1 (January 2023)