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show all sequences of 2.7.11.3

5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms

Hawley, S.A.; Selbert, M.A.; Goldstein, E.G.; Edelman, A.M.; Carling, D.; Hardie, D.G.; J. Biol. Chem. 270, 27186-27191 (1995)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
Rattus norvegicus
bicyclic phosporylation system, enzyme is believed to be involved in protecting cells against ATP depletion due to environmental stress by inactivating several key biosynthetic enzymes
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
Rattus norvegicus
phosphorylation activates EC 2.7.1.109
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
644976
Rattus norvegicus
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
bicyclic phosporylation system, enzyme is believed to be involved in protecting cells against ATP depletion due to environmental stress by inactivating several key biosynthetic enzymes
644976
Rattus norvegicus
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
phosphorylation activates EC 2.7.1.109
644976
Rattus norvegicus
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
Rattus norvegicus
bicyclic phosporylation system, enzyme is believed to be involved in protecting cells against ATP depletion due to environmental stress by inactivating several key biosynthetic enzymes
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
Rattus norvegicus
phosphorylation activates EC 2.7.1.109
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
644976
Rattus norvegicus
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
bicyclic phosporylation system, enzyme is believed to be involved in protecting cells against ATP depletion due to environmental stress by inactivating several key biosynthetic enzymes
644976
Rattus norvegicus
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
phosphorylation activates EC 2.7.1.109
644976
Rattus norvegicus
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
Other publictions for EC 2.7.11.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
644998
Hamilton
AMP-activated protein kinase k ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
293
892-898
2002
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1
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1
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1
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1
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1
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2
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644977
Hawley
Characterization of the AMP-ac ...
Rattus norvegicus
J. Biol. Chem.
271
27879-27887
1996
1
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2
1
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3
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1
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1
1
2
1
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1
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2
1
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1
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2
1
1
2
1
-
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-
644976
Hawley
5'-AMP activates the AMP-activ ...
Rattus norvegicus
J. Biol. Chem.
270
27186-27191
1995
-
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-
-
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2
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1
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1
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1
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3
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644972
Weekes
Activation of rat liver AMP-ac ...
Rattus norvegicus
Eur. J. Biochem.
219
751-757
1994
3
-
-
-
-
-
1
-
1
1
-
1
-
1
-
-
1
-
-
1
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3
-
1
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1
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3
-
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1
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1
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1
1
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1
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1
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1
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3
-
1
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-
-
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644973
Beg
In vivo modulation of rat live ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Proc. Natl. Acad. Sci. USA
81
7293-7297
1984
1
-
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1
1
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2
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162
-
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1
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2
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4
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1
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1
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1
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1
1
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2
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1
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2
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4
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1
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1
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644975
Beg
Human hepatic 3-hydroxy-3-meth ...
Homo sapiens
Biochem. Biophys. Res. Commun.
119
488-498
1984
-
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-
-
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1
1
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1
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2
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1
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1
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1
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2
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1
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1
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286565
Ingebritsen
Regulation of liver hydroxymet ...
Rattus norvegicus, Rattus norvegicus Wistar
J. Biol. Chem.
256
1138-1144
1981
1
-
-
-
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1
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2
1
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2
-
166
-
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1
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1
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4
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1
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1
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1
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1
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2
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1
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1
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4
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1
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644971
Beg
Characterization and regulatio ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
76
4375-4379
1979
1
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1
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2
1
1
2
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1
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1
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1
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6
-
2
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1
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1
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1
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1
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1
1
2
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1
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1
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6
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2
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1
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1
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644953
Ingebritsen
Reversible modulation of the a ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
81
1268-1277
1978
-
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1
1
1
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1
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1
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1
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1
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