Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.3 extracted from

  • Beg, Z.H.; Stonik, J.A.; Brewer, B.
    Human hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: evidence for the regulation of enzymic activity by a bicyclic phosphorylation cascade (1984), Biochem. Biophys. Res. Commun., 119, 488-498.
    View publication on PubMed
Search for more literature for 2.7.11.3

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement, actual substrate: MgATP Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Homo sapiens phosphorylation activates EC 2.7.1.109 ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 Homo sapiens ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] phosphorylation activates EC 2.7.1.109 Homo sapiens ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens