BRENDA - Enzyme Database show
show all sequences of 2.7.11.3

In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone

Beg, Z.H.; Stonik, J.A.; Brewer, B.; Proc. Natl. Acad. Sci. USA 81, 7293-7297 (1984)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
Mevalonolactone
activation, in vitro and in vivo
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
predominant
Rattus norvegicus
5829
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
requirement, actual substrate: MgATP
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
Rattus norvegicus
phosphorylation activates EC 2.7.1.109
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
Rattus norvegicus Sprague-Dawley
phosphorylation activates EC 2.7.1.109
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
Sprague-Dawley
-
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-
Purification (Commentary)
Commentary
Organism
partial
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
644973
Rattus norvegicus
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
phosphorylation activates EC 2.7.1.109
644973
Rattus norvegicus
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
644973
Rattus norvegicus Sprague-Dawley
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
phosphorylation activates EC 2.7.1.109
644973
Rattus norvegicus Sprague-Dawley
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
-
Rattus norvegicus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Rattus norvegicus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
Mevalonolactone
activation, in vitro and in vivo
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
predominant
Rattus norvegicus
5829
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
requirement, actual substrate: MgATP
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
Rattus norvegicus
phosphorylation activates EC 2.7.1.109
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
Rattus norvegicus Sprague-Dawley
phosphorylation activates EC 2.7.1.109
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
partial
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
644973
Rattus norvegicus
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
phosphorylation activates EC 2.7.1.109
644973
Rattus norvegicus
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
644973
Rattus norvegicus Sprague-Dawley
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
phosphorylation activates EC 2.7.1.109
644973
Rattus norvegicus Sprague-Dawley
ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
-
-
-
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
-
Rattus norvegicus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
assay at
Rattus norvegicus
Other publictions for EC 2.7.11.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
644998
Hamilton
AMP-activated protein kinase k ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
293
892-898
2002
-
-
1
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
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-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
644977
Hawley
Characterization of the AMP-ac ...
Rattus norvegicus
J. Biol. Chem.
271
27879-27887
1996
1
-
-
-
-
-
-
-
-
-
2
1
-
3
-
-
1
-
-
2
1
1
2
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
1
-
2
1
1
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
644976
Hawley
5'-AMP activates the AMP-activ ...
Rattus norvegicus
J. Biol. Chem.
270
27186-27191
1995
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
1
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3
-
-
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-
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2
-
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1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
644972
Weekes
Activation of rat liver AMP-ac ...
Rattus norvegicus
Eur. J. Biochem.
219
751-757
1994
3
-
-
-
-
-
1
-
1
1
-
1
-
1
-
-
1
-
-
1
-
-
3
-
1
-
-
-
-
-
-
1
-
-
-
3
-
-
1
-
-
-
-
1
-
-
1
1
-
1
-
-
-
1
-
1
-
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
644973
Beg
In vivo modulation of rat live ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Proc. Natl. Acad. Sci. USA
81
7293-7297
1984
1
-
-
-
-
-
-
-
1
1
-
2
-
162
-
-
1
-
-
2
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
-
1
-
2
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
644975
Beg
Human hepatic 3-hydroxy-3-meth ...
Homo sapiens
Biochem. Biophys. Res. Commun.
119
488-498
1984
-
-
-
-
-
-
-
-
1
1
-
1
-
2
-
-
1
-
-
1
-
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2
-
1
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-
-
1
-
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-
-
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-
-
-
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-
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-
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1
1
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1
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1
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1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
286565
Ingebritsen
Regulation of liver hydroxymet ...
Rattus norvegicus, Rattus norvegicus Wistar
J. Biol. Chem.
256
1138-1144
1981
1
-
-
-
-
-
1
-
2
1
-
2
-
166
-
-
1
-
-
1
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
1
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1
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2
1
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2
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1
-
1
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
644971
Beg
Characterization and regulatio ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
76
4375-4379
1979
1
-
-
-
-
-
1
-
2
1
1
2
-
1
-
-
1
-
-
1
-
-
6
-
2
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
2
1
1
2
-
-
-
1
-
1
-
-
6
-
2
-
-
-
1
-
-
1
-
-
-
-
-
-
644953
Ingebritsen
Reversible modulation of the a ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
81
1268-1277
1978
-
-
-
-
-
-
1
1
1
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
-
-
-
-
1
1
1
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
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-
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