Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-Aza-9-deaza-AMP | activation, i.e. formycin A-5'-monophosphate, can replace AMP | Rattus norvegicus | |
8-Aza-9-deaza-IMP | slight activation, i.e. formycin B-5'-monophosphate | Rattus norvegicus | |
additional information | no activation by formycin A or B | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosine(5')tetraphospho(5')adenosine | i.e. AP4A, inhibits in the presence of AMP | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement, actual substrate: MgATP | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | Rattus norvegicus | phosphorylation activates EC 2.7.1.109 | ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | i.e. AMP-activated protein kinase | Rattus norvegicus | ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | - |
? | |
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | phosphorylates catalytic subunit of EC2.7.1.109 | Rattus norvegicus | ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | - |
? | |
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | phosphorylation activates EC 2.7.1.109 | Rattus norvegicus | ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
AMP | allosteric activator, the allosteric effect and the promotion of phosphorylation and activation by the kinase kinase are due to binding of AMP to a single site on the kinase | Rattus norvegicus |