Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.3 extracted from

  • Ingebritsen, T.S.; Parker, R.A.; Gibson, D.M.
    Regulation of liver hydroxymethylglutaryl-CoA reductase by a bicyclic phosphorylation system (1981), J. Biol. Chem., 256, 1138-1144.
    View publication on PubMed
Search for more literature for 2.7.11.3

Activating Compound

Activating Compound Comment Organism Structure
additional information cAMP-independent enzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by inhibitor of cAMP-dependent protein kinase Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol predominant Rattus norvegicus 5829
-
additional information subcellular distribution Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement, actual substrate: MgATP Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Rattus norvegicus phosphorylation activates EC 2.7.1.109 ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Rattus norvegicus Wistar phosphorylation activates EC 2.7.1.109 ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar
-
Rattus norvegicus Wistar
-
 Wistar
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] phosphorylation activates EC 2.7.1.109 Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 Rattus norvegicus Wistar ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] phosphorylation activates EC 2.7.1.109 Rattus norvegicus Wistar ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus