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Literature summary for 2.7.11.29 extracted from
- Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein (1987), J. Biol. Chem., 262, 9367-9373.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Trypsin | inactivation of activator subunit | Bos taurus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bos taurus | 5829 | - |
| soluble | - |
Bos taurus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 120000 | - |
alphabeta, 1 * 35000-50000 + 1 * 120000, SDS-PAGE and gel filtration, a catalytic subunit for phosphorylation and an activator subunit, activator subunit not required | Bos taurus |
| 155000 | 170000 | gel filtration | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + low-density lipoprotein receptor | Bos taurus | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | cortex | Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00118 | - |
casein as substrate | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + casein | phosphorylated by catalytic subunit, activator subunit not required | Bos taurus | ? | - |
? | |
| ATP + low-density lipoprotein receptor | - |
Bos taurus | ? | - |
? | |
| ATP + low-density lipoprotein-L-serine | enzyme is composed of a catalytic and an activator subunit, the specificity for low-density lipoprotein receptor is attributable to the latter | Bos taurus | ADP + low-density lipoprotein O-phospho-L-serine | - |
? | |
| ATP + tubulin | - |
Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | alphabeta, 1 * 35000-50000 + 1 * 120000, SDS-PAGE and gel filtration, a catalytic subunit for phosphorylation and an activator subunit, activator subunit not required | Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Bos taurus |
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Release 2023.1 (January 2023)
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