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Literature summary for 2.7.11.27 extracted from

  • Mukai, Y.; Hoshi, F.; Sato, S.
    Effect of fructose on the phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase in HepG2 cells stimulated with placental lactogen (2016), Birth Defects Res. B Dev. Reprod. Toxicol., 107, 206-210 .
    View publication on PubMed
Search for more literature for 2.7.11.27

Activating Compound

Activating Compound Comment Organism Structure
AMP
-
 Homo sapiens
fructose acetyl-CoA carboxylase phosphorylation by the enzyme increases significantly and concentration-dependently in fructose-treated HepG2 cells in the presence of placental lactogen Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [acetyl-CoA carboxylase] Homo sapiens the enzyme can directly inactivate acetyl-CoA carboxylase through phosphorylation of Ser79 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is activated through phosphorylation by liver kinase B1 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [acetyl-CoA carboxylase] the enzyme can directly inactivate acetyl-CoA carboxylase through phosphorylation of Ser79 Homo sapiens ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Homo sapiens
AMPK
-
 Homo sapiens