Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Wistar | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | determination of levels of hypothalamic phosphorylation of AMPK | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hypothalamus | determination of levels of hypothalamic phosphorylation of AMPK | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
AMPK | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | the reduction of hypothalamic acetyl-CoA carboxylase increases phophoenolpyruvate carboxykinase expression, AMPK phosphorylation, and glucose production in the liver. These effects are observed without modification of hypothalamic AMPK phosphorylation. Fasted rats show greater AMPK phosphorylation levels than fed rats. Reduced AMPK phosphorylation is linked to an increase in acetyl-CoA carboxylase activity and biosynthesis of malonyl-CoA | Rattus norvegicus |
physiological function | hypothalamic AMPK acts as a cell energy sensor and can modulate food intake, glucose homeostasis, and fatty acid biosynthesis. Intrahypothalamic fatty acid injection is known to suppress liver glucose production, mainly by activation of hypothalamic ATP-sensitive potassium (K(ATP)) channels | Rattus norvegicus |