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Literature summary for 2.7.11.26 extracted from

  • Magley, R.A.; Rouhana, L.
    Tau tubulin kinase is required for spermatogenesis and development of motile cilia in planarian flatworms (2019), Mol. Biol. Cell, 30, 2155-2170 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Schmidtea mediterranea
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis preferred expression Schmidtea mediterranea
-

Synonyms

Synonyms Comment Organism
tau tubulin kinase
-
 Schmidtea mediterranea
TTBK-a isoform Schmidtea mediterranea
TTBK-b isoform Schmidtea mediterranea
TTBK-c isoform Schmidtea mediterranea
TTBK-d isoform Schmidtea mediterranea
TTBK-e isoform Schmidtea mediterranea
TTBK-f isoform Schmidtea mediterranea

General Information

General Information Comment Organism
malfunction disrupting expression of isoform TTBK-d results in loss of spermatozoa, but not spermatids. In the soma, isoform TTBK-d RNAi impairs the function of multiciliated epidermal cells in propelling planarian movement, as well as the osmoregulatory function of protonephridia. Decreased density and structural defects of motile cilia are observed in the epidermis Schmidtea mediterranea
physiological function isoform TTBK-d is specifically required in postmeiotic regulation of spermatogenesis. Isoform TTBK-d is required for the structural integrity of planarian motile cilia and protonephridial units Schmidtea mediterranea