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Literature summary for 2.7.11.26 extracted from

  • Qi, H.; Prabakaran, S.; Cantrelle, F.X.; Chambraud, B.; Gunawardena, J.; Lippens, G.; Landrieu, I.
    Characterization of neuronal tau protein as a target of extracellular signal-regulated kinase (2016), J. Biol. Chem., 291, 7742-7753 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.26

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Xenopus laevis Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
D321N/D324N the mutant has reduced affinity for the D-site peptides Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + tau-protein Rattus norvegicus ERK2 phosphorylates Thr-50, Thr-153, Thr-175, Thr-181, Thr-205, Thr-231, Ser-235, Ser-404, and Ser-422 in tau-protein ADP + O-phospho-tau-protein
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
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neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + tau-protein ERK2 phosphorylates Thr-50, Thr-153, Thr-175, Thr-181, Thr-205, Thr-231, Ser-235, Ser-404, and Ser-422 in tau-protein Rattus norvegicus ADP + O-phospho-tau-protein
-
 ?

Synonyms

Synonyms Comment Organism
ERK2
-
 Rattus norvegicus
extracellular-regulated kinase
-
 Rattus norvegicus
tau protein kinase
-
 Rattus norvegicus
TPK
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function ERK2 dysregulation in Alzheimer's disease can lead to abnormal phosphorylation of Tau resulting in the pathology of the disease Rattus norvegicus