Any feedback?
Literature summary for 2.7.11.26 extracted from
- Tau tubulin kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases (2019), Eur. J. Med. Chem., 161, 39-47 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | isoform TTBK1 is a target for the treatment of neurodegenerative diseases | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-bromo-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzoate | - |
Homo sapiens | |
| 3-((5-((4-amino-4-methylcyclohexyl)amino)-pyrrolo[2,1-f][1,2,4] triazin-4-yl)amino)-5-bromophenol | - |
Homo sapiens | |
| 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + alpha-actin | Homo sapiens | - |
ADP + p35 | - |
? |  |
| ATP + mu-calpain | Homo sapiens | - |
ADP + calpastatin | - |
? | |
| ATP + tau-protein | Homo sapiens | isoform TTBK1 phosphorylates tau-protein at Ser198, Ser199, Ser202 and Ser422 | ADP + O-phospho-tau-protein | - |
? | |
| ATP + TDP-43 | Homo sapiens | - |
ADP + phosphorylated TDP-43 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q5TCY1 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| neuron | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + alpha-actin | - |
Homo sapiens | ADP + p35 | - |
? | |
| ATP + mu-calpain | - |
Homo sapiens | ADP + calpastatin | - |
? | |
| ATP + tau-protein | isoform TTBK1 phosphorylates tau-protein at Ser198, Ser199, Ser202 and Ser422 | Homo sapiens | ADP + O-phospho-tau-protein | - |
? | |
| ATP + TDP-43 | - |
Homo sapiens | ADP + phosphorylated TDP-43 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 230000, SDS-PAGE | Homo sapiens |
| ? | x * 142700, calculated from amino acid sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Tau tubulin kinase 1 | - |
Homo sapiens |
| TTBK1 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00012 | - |
isoform TTBK1, pH and temperature not specified in the publication | Homo sapiens | 3-((5-((4-amino-4-methylcyclohexyl)amino)-pyrrolo[2,1-f][1,2,4] triazin-4-yl)amino)-5-bromophenol |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | isoform TTBK1 is upregulated in the frontal cortex of patients with Alzheimer's disease | up |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
