Literature summary for 2.7.11.26 extracted from

Nieding, K.; Matschke, V.; Meuth, S.G.; Lang, F.; Seebohm, G.; Strutz-Seebohm, N.
Tau tubulin kinase TTBK2 sensitivity of glutamate receptor GluK2 (2016), Cell. Physiol. Biochem., 39, 1444-1452 .

Search for more literature for 2.7.11.26

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Xenopus laevis oocytes	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D163A	kinase-dead mutant	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + tau-protein	Homo sapiens	-	ADP + O-phospho-tau-protein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q6IQ55	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + tau-protein	-	Homo sapiens	ADP + O-phospho-tau-protein	-	?

Synonyms

Synonyms	Comment	Organism
tau tubulin kinase 2	-	Homo sapiens
TTBK2	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	isoform TTBK2 influences the function of the glutamate receptor GluK2. The enzyme down-regulates GluK2 activity by decreasing the receptor protein abundance in the cell membrane via RAB5-dependent endocytosis	Homo sapiens

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Release 2023.1 (January 2023)