Literature summary for 2.7.11.26 extracted from

Marcotte, D.J.; Spilker, K.A.; Wen, D.; Hesson, T.; Patterson, T.A.; Kumar, P.R.; Chodaparambil, J.V.
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor (2020), Acta Crystallogr. Sect. F, 76, 103-108 .

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Cloned(Commentary)

Cloned (Comment)	Organism
the tau tubulin kinase 2 kinase domain is expressed in Escherichia coli C2523 cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
enzyme complexed with the Cdk2 inhibitor WHI-P180, using 0.1 M Tris pH 8.5, 10% (v/v) glycerol, 2.0 M sodium/potassium phosphate at 4°C	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + tau-protein	Homo sapiens	tau tubulin kinase 2 phosphorylates tau-protein at Ser208 and Ser210	ADP + O-phospho-tau-protein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q6IQ55	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA agarose resin column chromatography and Superdex 75 gel filtration	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + tau-protein	tau tubulin kinase 2 phosphorylates tau-protein at Ser208 and Ser210	Homo sapiens	ADP + O-phospho-tau-protein	-	?

Subunits

Subunits	Comment	Organism
monomer	x-ray crystallography	Homo sapiens

Synonyms

Synonyms	Comment	Organism
tau tubulin kinase 2	-	Homo sapiens
TTBK2	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	inhibition of tau tubulin kinase 2 may lead to the movement disorder spinocerebellar ataxia type 11	Homo sapiens

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Release 2023.1 (January 2023)