Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | Rattus norvegicus | - |
ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | Rattus norvegicus Sprague-Dawley | - |
ADP + O-phospho-[tau-protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P18266 | - |
- |
Rattus norvegicus Sprague-Dawley | P18266 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | - |
Rattus norvegicus | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | tau phosphorylation at GSK-3beta sensitive but AMPK insensitive residues Ser202/Thr205 | Rattus norvegicus | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | - |
Rattus norvegicus Sprague-Dawley | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | tau phosphorylation at GSK-3beta sensitive but AMPK insensitive residues Ser202/Thr205 | Rattus norvegicus Sprague-Dawley | ADP + O-phospho-[tau-protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3beta | - |
Rattus norvegicus |
GSK-3beta | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | abnormal tau phosphorylation (p-tau) occurs after hypoxic damage to the brain associated with traumatic brain injury and stroke | Rattus norvegicus |
physiological function | glycogen synthase kinase-3 (GSK-3beta) and protein phosphatase 2A (PP2A) are thought to control the levels of tau phosphorylation. No alteration in the activities of GSK-3beta and PP2A during episodes of ischaemia of up to 8 min and reperfusion of up to 2 h, and 4 weeks recovery. Tau dephosphorylation following ischaemia is not dependent on GSK-3beta or PP2A activity, but is associated with AMPK dephosphorylation | Rattus norvegicus |