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Literature summary for 2.7.11.26 extracted from

  • Majd, S.; Power, J.H.; Koblar, S.A.; Grantham, H.J.
    Early glycogen synthase kinase-3beta and protein phosphatase 2A independent tau dephosphorylation during global brain ischaemia and reperfusion following cardiac arrest and the role of the adenosine monophosphate kinase pathway (2016), Eur. J. Neurosci., 44, 1987-1997.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [tau-protein] Rattus norvegicus
-
ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein] Rattus norvegicus Sprague-Dawley
-
ADP + O-phospho-[tau-protein]
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P18266
-
-
Rattus norvegicus Sprague-Dawley P18266
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [tau-protein]
-
Rattus norvegicus ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein] tau phosphorylation at GSK-3beta sensitive but AMPK insensitive residues Ser202/Thr205 Rattus norvegicus ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein]
-
Rattus norvegicus Sprague-Dawley ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein] tau phosphorylation at GSK-3beta sensitive but AMPK insensitive residues Ser202/Thr205 Rattus norvegicus Sprague-Dawley ADP + O-phospho-[tau-protein]
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3beta
-
Rattus norvegicus
GSK-3beta
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction abnormal tau phosphorylation (p-tau) occurs after hypoxic damage to the brain associated with traumatic brain injury and stroke Rattus norvegicus
physiological function glycogen synthase kinase-3 (GSK-3beta) and protein phosphatase 2A (PP2A) are thought to control the levels of tau phosphorylation. No alteration in the activities of GSK-3beta and PP2A during episodes of ischaemia of up to 8 min and reperfusion of up to 2 h, and 4 weeks recovery. Tau dephosphorylation following ischaemia is not dependent on GSK-3beta or PP2A activity, but is associated with AMPK dephosphorylation Rattus norvegicus