Inhibitors | Comment | Organism | Structure |
---|---|---|---|
kenpaullone | - |
Mus musculus | |
LiCl | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | 1-methyl-4-phenylpyridinium iodide treatment induces a significant decrease of the specific phospho-Tyr216-GSK-3beta labeling in mitochondria concomitantly with an increase into the cytosol | Mus musculus | 5829 | - |
mitochondrion | GSK-3beta partially localizes within mitochondria | Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | GSK-3beta is activated by phosphorylation of the tyrosine 216 residue located in the kinase domain and inactivated by phosphorylation of the amino-terminal serine 9 residue | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | - |
Mus musculus | - |
TSM1 cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3beta | - |
Mus musculus |
GSK-3beta | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | GSK-3beta is a critical mediator of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/1-methyl-4-phenylpyridinium iodide-induced neurotoxicity through its ability to regulate mitochondrial functions | Mus musculus |