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Literature summary for 2.7.11.26 extracted from

  • Min, W.W.; Yuskaitis, C.J.; Yan, Q.; Sikorski, C.; Chen, S.; Jope, R.S.; Bauchwitz, R.P.
    Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential (2009), Neuropharmacology, 56, 463-472.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.26

Application

Application Comment Organism
medicine GSK3 is a fundamental and central component of Fragile X syndrome pathology Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
AR-A014418 selective ATP-competitive inhibitor of GSK3 Mus musculus
lithium
-
 Mus musculus
SB-216763 selective ATP-competitive inhibitor of GSK3 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein tau Mus musculus
-
 ADP + protein tau phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation on serine-21 of GSK3alpha and serine-9 of GSK3beta greatly inhibits the activity of GSK3 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain cortex
-
 Mus musculus
-
cerebellum
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-
striatum
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau
-
 Mus musculus ADP + protein tau phosphate
-
 ?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3
-
 Mus musculus
GSK3
-
 Mus musculus
GSK3alpha isoform Mus musculus
GSK3beta isoform Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus