Any feedback?
Literature summary for 2.7.11.26 extracted from
- Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in myocardial protection against ischemia/reperfusion injury (2009), J. Pharmacol. Sci., 109, 162-167.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | a significant inverse correlation is observed between level of phospho-GSK-3beta at the time of reperfusion and the extent of myocardium infarction in heart, phospho-GSK-3beta is a determinant of myocardial tolerance against reperfusion-induced necrosis. Thus, GSK-3beta is a target of therapy for cardioprotection upon reperfusion. Inactivation of GSK-3beta by phosphorylation at Ser9 elevates the threshold for mitochondrial permeability transition pore opening, which reduces myocyte necrosis. | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + p53 | - |
Homo sapiens | ADP + p53 phosphate | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycogen synthase kinase-3beta | - |
Homo sapiens |
| GSK-3beta | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | inactivation of glycogen synthase kinase-3beta suppresses mitochondrial permeability transition pore opening and protects cardiomyocytes | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
